When you look at lists of the most reliable six-pots ever built, you usually find a whole lot of straight-sixes. An inline-six engine offers a number of advantages over a V6, the main one being that it has all its ducks in a row, so to speak. With a straight line of cylinders, you don't have to worry about balancing two banks of odd-numbered cylinders side by side.But, it's not fair to say that all straight sixes are better than any V6 you could put them up against. Engine makers like Toyota and Nissan have done some excellent work with V6 powerplants, and they deserve some commendations. These ten engines prove that a V6 can do anything an i6 can do.The following V6 engines have been selected based on their reputation for longevity and the existence of high-mileage models. Honda J35 VTEC V6 The Longest-Running Member Of The Iconic J Family Vtec 35Honda OdysseyAcura MDX Honda Legend Saturn Vue Honda RidgelineWe could fill this whole list with J engines, the legendary V6 motors that have been pushing Hondas and Acuras along since 1999, but the J35 in particular is a trooper, powering everything from the Odyssey to the Pilot to the Acura MDX and serving as the basis of the Honda Marine BF200 engine.The J engine first hit the scene in 1996, and it's still in use today. The engine's reliability owes a lot to the use of heat-resistant aluminum, as well as efficient performance. The J family can actually disable a cylinder bank, operating as a straight-three for light workloads. Toyota 5VZ-FE 3.4 V6 Toyota's Go-To V6 For Rugged '90s Pickups And SUVs Toyota T100Toyota Land Cruiser Prado Toyota T100 Toyota TacomaToyota 4RunnerToyota TundraToyota may be the first name to crop up when you think of reliable V6s. Picking out a half dozen of these motors from Toyota is almost too easy, so we're going old-school with the 5VZ-FE, a V6 that powered Toyota's heavier-duty vehicles through the 1990s, including the Tacoma, the 4Runner, and the forgotten semi-full-size T100 pickup.The VZ family was in production from 1988 to 2004, with the 5VZ-FE being available in the late 1990s and early 00s. The engine is built on a cast-iron block and aluminum head, with a cast aluminum intake manifold, cast connecting rods, and a one-piece cast camshaft. TRD developed a bolt-on supercharger kit for the engine, boosting the output to 254 hp.Check any Toyota forum on the web, and you'll find at least a few T100 owners bragging about hitting 300,000 miles or more in their 3.4-liter pickups, like NCPAPAUL on ToyotaNation.com, who reports buying it used in 2002 with just 90,000 miles on it, and hitting 300,000 back in 2014. Nissan VR30DDTT The VR30 Twin-Turbo Carried The Nissan Z To 400 Horsepower 2016 Infiniti Q50Infiniti Q50Infiniti Q60 Nissan Skyline Nissan Z The Nissan VR30DDTT is part of the VR family, which launched in 2007 and remains in production today. Aluminum blocks, aluminum heads, sprayed mirror coating for the cylinder bores, and a pair of direct-mount turbos. The VR30DDTT scored a place on Ward's 10 Best Engines list for both 2017 and 2018. Here in the US we primarily know the VR30 for its use in the Infiniti Q60 and Q60.In the Nissan Z, the engine produces up to 420 hp. Tuners have gotten that number considerably higher. AMS Performance has hotrodded this engine up to 1,034 hp in the Q50, so it should have no trouble handling your daily commute for half a million miles. Assuming you drive it unmodified, that is. Buick 3800 V6 The Buick 3800 Had A Long, Long Run 1990 Buick Reatta (1) Oldsmobile Toronado Pontiac Bonneville Buick LeSabre Buick Electra Buick Riviera One of the older motors on this list, the Buick 3800 was initially known as the Fireball V6 and loaded into the 1962 Buick Special, as a 3.2-liter engine. The 3800 came about in 1988, with a cast-iron body and a simple DOHC design, resulting in an engine that you'd have a hard time killing with a pneumatic drill, if it came to that. As a user in the r/MechanicAdvice subreddit puts it "My LeSabre has 345,000 miles on it. Body rusted out before the engine gave out. Still spins tires in second gear." Duratec 35 Cyclone The Signature Engine For The Short-Lived Taurus X Cyclone35Ford EdgeLincoln MKZMazda CX-9 Ford Taurus X Ford Fusion SportFord ExplorerThe Duratec 35 Cyclone is noted for its robust build and naturally-aspirated power delivery. Aluminum block, aluminum head, and water-cooled, the engine first went into production for the 2007 model year, for Fords and Lincolns like the Edge and the MKX. A twin-turbo EcoBoost variant is still in production as a crate engine from Ford Power Products, although the original Duratec 35 Cyclone hasn't been factory mounted since the 2019 model year. 3.6 Pentastar V6 The 3.6 Pentastar V6 Could Be A Million-Miler, But It's Here For A Good Time, Not For A Long Time 2012 Jeep Wrangler (1)Jeep WranglerJeep GladiatorChrysler 300Dodge JourneyJeep Grand CherokeeThe thing about Jeeps: it's not that they're unreliable, it's that they attract a certain kind of buyer who maybe doesn't know how to approach a heavy-duty off-roading adventure. They bust the suspension and bend the axle their first time out, give up on fixing it, and pawn it off on whatever rube will buy it. Jeeps can be very reliable, and the Pentastar 3.6 proves it. These motors often surpass a quarter million miles and more thanks to their robust aluminum blocks and heads, with cast-iron bore liners.While it's not hard to find Jeep owners with a quarter-million miles on a Pentastar, we've noted in the past how few Jeeps seem to reach seven-digits on the odometer. As near as we can figure, it has more to do with who's driving a Wrangler than with what's under the hood. These are adventure vehicles, they're not being driven by people who are doing long-haul courier work. Lots of short excursions into the woods, across creeks and down muddy roads, it wears even the most reliable engines down pretty quick. GM 4.3 Small-Block V6 The Base Engine For Full-Size GM Trucks From 2014 1985 El Camino (1)Chevrolet Impala Chevrolet S-10 Blazer Chevrolet C/K Chevrolet El Camino Chevrolet SilveradoThe Chevrolet 90° V6 engine was put into production all the way back in 1978, with the Gen I 4.3-liter V6 powering utes and muscle cars of the era like the El Camino and the Monte Carlo. To give you an idea of the faith GM had in this motor, this thing was still in production as late as 2014, when it was powering the Chevy Silverado. You can attribute the engine's reliability largely to the simple fact that it's based on the legendary small-block V8 family. Nissan 3.0 VQ30DE American Drivers Will Know The VQ30DE For The 2000-2001 Nissan Maxima 1999 Nissan Maxima (2)Nissan Maxima Nissan Gloria Nissan Bassara Nissan Presage Infiniti I30 This is another one of those engine families where you could pick any one from the lineup and easily put half a million miles on it. We like the VQ30DE for its placement on the Ward's 10 Best Engines list seven years straight, from 1995 to 2001, and for its use in the 2000 Maxima, where it produced 222 hp without a turbocharger. The VQ family has been in production since 1994, with aluminum blocks and heads, and countless incremental improvements over the years. Honda C35A The 3.5 In "Acura 3.5RL" 2001 Acura RL (1) Honda Legend Acura Legend Acura 3.5RLIf you've driven one of these in America, it was probably in an Acura 3.5RL. These cars pop up from time to time in the Mileage Impossible Facebook group, with one user in particular showing off a 273,372-mile 2002 model early last year. The whole C series is pretty dependable, but the C35A is extra tough for the simple fact that it's larger than the C32A, but retains that motor's 9.6:1 compression ratio, so, unless some hot-rodders have had at it, you're running a slightly larger engine like a slightly smaller engine. Toyota 2GR-FE The Toyota 2GR-FE Is Simply Unkillable 2015-2017 Toyota Camry 7th Gen Engine Toyota Avalon Toyota Camry Lexus ES 350 Lexus RX 350 Toyota SiennaBuilt on a die-cast aluminum block, using timing chains instead of belts, and featuring some of the tightest tolerances in the industry, the 2GR-FE is incredibly popular among engine-swappers for its robust build, forged components, and versatility. The motor was first introduced for the 2005 model year, with the original version still in use today in the Lotus Evora, which we called the "mid-engine supercar with Toyota reliability."Sources: Toyota, Honda, Ford, GM, Nissan.